As i analised, I see that there is place for A40, but Duisburg should be rebuild or delete, as I paint red on the map and red point can be Venlo (beyond the border also can be do some logistic centers or factories how it is real). There is a place for A28 from Zwolle to Utrecht and then A27 to A58 ...

I definitely agree with this one. Also especially at highways, there are not enough places where you can turn when you for example took the wrong way or there is a detour.

Suggestions:
-Utrecht, the middle of the Netherlands, all roads come together here.
-Lommel, just at the border in Belgium, near Eindhoven/Antwerpen/Liège, with the Kristalpark, and industriegebied Balendijk.
-Port of Zeebrugge
-Road Luxemburg to Koblenz, via Trier.
-Charleroi
-Enschede